However, the grapefruit chemicals impair the action of CYP3A4, allowing the bioactivity of some medications to reach much higher levels than normal, potentially producing adverse effects.
Furanocoumarin chemicals are also found in Seville oranges used to make marmalade , limes, and pomelos, but not in sweet oranges such as navels and Valencias. Even a relatively small amount of grapefruit can have a large effect on drug concentration levels. For example, a single serving of grapefruit juice ml or a whole grapefruit combined with the antihypertensive felodipine has been shown to yield a systemic drug concentration 3 times that seen with equivalent water intake.
Repeated intake led to even larger effects; drinking ml of grapefruit juice 3 times per day for 6 days led to a systemic drug concentration 5 times that seen with water. However, the effect can vary greatly from patient to patient. Different individuals who took felodipine with a ml serving of grapefruit juice had systemic concentrations ranging from 0 to 8 times that observed with water. The result: too much drug in your body. The answer as to whether or not someone can potentiate opioids is YES.
However, doing so is extremely dangerous. The National Institute on Drug Abuse, NIDA, reports that drug potentiation, which is often combining opioids with other substances, particularly other substances that affect the respiratory system such as alcohol or benzodiazepines increases the chances of a fatal accidental overdose. Combining opioids and benzodiazepines can be unsafe because both types of drugs sedate users and suppress breathing—the cause of overdose fatality.
In , 23 percent of people who died of an opioid overdose also tested positive for benzodiazepines. Evoke Florida has been providing specialized treatment programs for opioid addicts who potentiate their opiate drugs. Our treatment programs for opioids and their potentiators address multi-substance addiction in its entirety.
Since addiction is a treatable condition, our clients get treatment for all of their drug use, which includes potentiators. This is critical considering that many opiate addicts will remain clean from heroin or other opiates but switch to abusing a potentiator, such as alcohol or benzodiazepines, or over the counter medications. The steps we take to help our clients come to terms with all of their addictions, not just their drug of choice or primary addiction to an opiate, begins with our medically supervised detox.
Our detox programs are overseen by medical practitioners who specialize in addiction. They utilize their training and education to recognize when the presence of other drug withdrawal symptoms occur, which indicate addition or use. Additionally, every client has full panel blood work and physical examinations, which also help reveal what types of drugs are in their system. Our opioid detox prescribes safe medications that eliminate opioid withdrawal symptoms.
Each client is allowed to rest and recover during their detoxification. Our detox center offers care for opiate addiction with potentiated drug use. Once a client completes our Florida opioid detox , they are encouraged to enter one of our specialized drug treatment programs. Maintaining a passion for words, she took on a variety of projects where her writing could help people especially those battling mental health and substance use disorders.
All of the information on this page has been reviewed and verified by a certified addiction professional. David embarked on his journey into sobriety in June of , which led him to his current career path as a Certified Professional Addiction Recovery Coach in private practice in Greater Nashville.
David is also a public speaker and the author of two books. David is cohost of the weekly Positive Sobriety Podcast, as well as being a frequent contributor to various articles and recovery based materials.
As a member of the National Association of Alcohol and Drug Abuse Counselors NAADAC , David works closely with Nashville area treatment centers, nonprofit recovery organizations, and consulting with faith-based groups trying to bridge the gap between the recovery communities and faith-based organizations who wish to understand addiction. Lancaster, SC. View Center. Asheville, NC.
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Chats will be received and answered by one of treatment providers listed below, each of which is a paid advertiser:. Hydrocodone Addiction And Abuse Hydrocodone addiction may begin as a result of prescription Opioid abuse. Symptoms of Hydrocodone abuse include drowsiness, pinpoint pupils, and flushed skin. Start the road to recovery. Get a Call. Questions about treatment? Call now for: Access to top treatment centers Caring, supportive guidance Financial assistance options Addiction Center is not affiliated with any insurance.
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